The study appears in the journal Molecular Therapy Nucleic Acids.The therapeutic effect lasted 120 days in treated mice.

The condition is one of the most common causes of blindness in children, according to the National Institutes of Health, affecting two to three of every 100,000 newborns.Leader Zheng-Rong Lu said that they believe this technology can deliver almost any type of gene to tackle inherited visual disorders.While other researchers focus on using modified viruses to deliver genes for therapy, sometimes the genes are too large for viruses to carry, Lu said. The protein is an essential constituent of the visual cycle that converts light to electrical signals to the brain.: A new gene-delivery system for an inherited form of blindness shows promise, according to a recent study.Researchers at Case Western Reserve University have developed gene-carrying nanoparticles that home in on target cells and prevent vision loss in mice with a human form of Leber congenital amaurosis.

They are also studying whether the nanoparticles can be used with the CRISPR/Cas9 gene-editing technique to treat genetic lesions related to retinal degenerative diseases.Though this research focused on the form of the disease called Leber congenital amaurosis 2, or LCA2, the scientists and engineers involved in the study believe the technology holds promise for other forms of LCA as well as other inherited diseases that lead to severe vision loss or blindness. The mutated gene fails to produce RPE65 protein in the retinal pigment epithelium (RPE), a cell layer critical for protecting photoreceptors (rods and cones). To track activity, Lus team included a fluorescent markerFollowing injection into the retina of mice,

“It also has detachable sponges for maintenance. “At home, I had an almirah filled with the stuff I was making,” explains the 74-year-old innovator. The centre started with facilitating about 45-odd start-ups that soon became profitable companies.

The idea was to give people the ability to create innovative products to solve problems in their daily lives. Not just that, the innovators would be given a chance to exhibit their ideas. An initiated of Gaurang Shetty, CEO of Riddl, the customised maker initiative also exposes these energetic minds to their labs, in order to improve their products over a period of the two day fair.” While Armaan’s machine is still a model, he plans to produce more of these soon.Janaki and Girija are currently part of a unique fair called Maker Mela, which looks to host innovators, helping them find the right market.

Armaan Gupta working at his station at the mela“There are many young girls as well creating amazing stuff, but they don’t have a place to showcase it.“Our end is to create an opportunity for people,” he adds. Armaan’s contraption mops and dries the floor, simultaneously. “And we’ve created more than 200 job opportunities through our incubators.As a result, Amma Ki Almaari was born.Besides India, the mela has seen innovators from Taiwan, US and Europe over the past two years.The bamboo spinning wheel by Japanese innovator Hideo Oguri can be used anywhereRiddl, explains Garang, was set up in 2010 as an innovation centre and business incubator. To save myself, https://www.signs-factory.com/product/illuminated-sign/light-box-letter/ China light box signs Suppliers I came up with this mop,” grins Armaan. And both machines can be used anywhere!”Seeing the enthusiasm of the innovators, Gaurang hopes to take the mela abroad, starting with a mini version in Bangladesh.

And through this mela, we generate about 1,000 opportunities every year!”The Maker MelaOngoing till January 13, At Somaiya VidyaVihar.“I used to spill juice on the floor and get scolded by my mother. They now even have over 50 women on board from all over India, and the duo also help them curate products. Today, Amma Ki Almaari is more than just crochet — it’s an almari of different art and craft, all handmade,” explains Chatty Girija, who helps her mother Janaki runs the business. This time, 58-year-old Japanese innovator, Hideo Oguri is present. “The dehydrator has the capacity of only two clothes at the moment, but I plan to increase that.“The spin line is based on Mahatma Gandhi’s Charkha,” says Hideo.”Amma Ki AlmaariThe result sees the likes of 10-year-old Armaan Gupta, who is the creator of a remote-controlled cleaning and mopping machine. “As the almirah started filling up with material, my daughter thought of turning it into a business.And as innovators started to crowd in from across the world, Gaurang turned it into a mela, which now hosts 100 teams with three innovators in each.

“This concept is quite popular in the West, and we wanted to start something similar in India, but at a much evolved level.“We realised that building a community was useful, as alumni from Riddl started to come back to help the new start-ups,” smiled Gaurang.Having practiced crochet since the age of six, Chatty Janaki never imagined she’d make a business out of it. It was only three years ago that her daughter realised that there were more ‘ammas’ like her own, who had talent worth bringing to light. Starting off as only a destination for crochet work, Janaki now has an expansive spread of fabric art, wood art, and handmade jewellery. Hideo has made a spin line for cotton and a dehydrate laundry machine, which runs without electricity.

Not only was he a fabulous albeit a dark painter, his writing skills were admirable too. Says Vijay, “He would always be Mani Kaka ever since his visits to our home in Delhi in the 50s. That is my state for many years now and even if I want to draw something else, it is Radha that appears on my canvas.“His work is evolved and there is a strange quality juxtaposing joy and sorrow in the environment and the routine projections of daily life in his paintings.

At an art camp in Shantiniketan many years ago, I asked him why it was Radha more than any other character that interested him. We called him Kaka and his wife Sushila Masi since both studied at Shantiniketan during the time my parents were there. By this time, he had a large following of his students who had become established artists in their own right.”On the other hand, Suhas Roy was this gentle soul whose tobacco- and paan-stained teeth would peep from behind his ever-smiling countenance. Not the type to dwell on sorrow, illness or any other negativity, he remained cheerful till the end.I will always recall Mani da as a slightly serious person wearing a south Indian lungi, who spoke little and saw much more.His deep involvement with crafts is well known and his work with the weavers and crafts persons has been much hailed. He penned and sketched a number of books for children, which have been very popular. I had gone to meet him at E. The trio I am referring to is Yusuf Arrakal, K. To bring out that intensity, I do not think that any colour other than stark black would have worked. Subramanyan and Suhas Roy. He was very skilled with his hands and made small toys for us with paper, strings or whatever he got in his hands. He was very fond of plying one with wine, books — including some that he had written — and good conversation.” K.”I accused him of being eccentric and pat came the answer: “It is news to me that I am eccentric! But I have always stood up to fight for issues I believed in, not fearing of the consequences!” And he guffawed.

One of his works in which he took enormous pride was the “sculpturesque” car and auto rickshaw he created from a real car and auto rickshaw. I am in a way aiming at creating very intense faces that I have envisaged and studied from life. He dressed young and in excellent if sometimes flamboyant taste in denims and corduroys and thought very young — no wonder that he had many young artist friends who rallied around him. I have had many wonderful moments guzzling beer with Yusuf in Bangalore, where his wicked sense of humour and wit kept us in splits as it was irreverent and had no taboo areas — you could ask him anything and he gave a straight answer no matter how tricky the question and expected you to do the same.G. “What is life if you don’t live it till the bitter end!” is one remark of his that is vividly stuck in my memory. Subramanyan galvanised the department into a dynamic throbbing entity, encouraging each student to think independently and develop his own path. He used colours with great spontaneity sometimes as a backdrop to his powerful drawings. Alkazi’s gallery Art Heritage and then at Amal Allana’s beautiful home he became more relaxed and talked about many issues and concerns about art in general and Indian art in particular. Here is wishing all of a wonderful Diwali!

Dr Alka Raghuvanshi is an art writer, curator and artist and can be contacted on alkaraghuvanshiyahoo. He was elected to the World Craft Council, he was a delegate to the Asian Assembly and World Craft Council, Sydney, and was member delegate, General Assembly, World Craft Council, Oaxtepec, Mexico.” Later, as the reader and professor at the faculty of fine arts in Baroda, K. His opinion of which way contemporary Indian art was headed was equally candid: “Do you really want me to answer this question Frankly, I do not know where it is heading, if at all it is heading to any direction. An art fair was started at Baroda and he was responsible for the development of very interesting toys in wood and clay apart from the paintings, graphics and sculptures. Here the darkness gave way to Custom Badge Signs Suppliers satire and black humour. These last few months, the art world has lost three important artists and during this festive period, I want to remember the happy interactions that I had with them. Nothing surprised him and yet he retained his humour. His animal drawings were very strong with intense simplicity,” says Vijay. The content in his work had a lot of humour and often a satire of everyday situations. He liked to experiment with various materials and has made works in terracotta, ceramics, cement castings with sand moulds, bamboo and wood, and reverse painting acrylic paint on acrylic sheet among others.

I am of the firm conviction that it is important to remember one’s gurus and loved ones during festivals and such happy occasions for they were once an intrinsic and important part of one’s life and times, and not remember them with sorrow but with gratitude for the meaningful and happy moments spent with them. I learned very early that if you have to sustain in life and in your chosen vocation, you have to stand up and sort out the problem, rather than getting into a mood of dejection and trying to run away from it. He also wrote deep thought-provoking books on art, art education and attitudes to art. I remembered I once asked him why his series of faces was surrounded by black, and he had replied rather matter-of-factly: “I tend to paint towards darker tones; be it browns, blues or black. Despite royal blood from Kerala, his personal struggle was immense and instead of making him bitter, it only made him a person whose scandal meter was zero. He was known for making portraits of Radha almost to the point where it became his signature.G. His other strength was his writing.

There are some periods when I am besotted with problems in my work and life in general, but I never get into a mood of despondency or dejection. His thoughts were conveyed through these and the writing was clear and precise, conveying the essence with strength and conviction. Subramanyan, fondly known as Mani, Mani sir and Mani da, meant many things to people and an ongoing exhibition at the India International Centre of his work curated by artist Vijay Kowshik explores his myriad dimensions. “Radha is not a person, it is a bhava — a bhava of love.And as I said at the outset, this piece today is all about cherished memories of our seniors who have been pathfinders of sorts. I loved his river series of paintings as well.G. I sincerely hope that it is not heading to disaster.