The study appears in the journal Molecular Therapy Nucleic Acids.The therapeutic effect lasted 120 days in treated mice.
The condition is one of the most common causes of blindness in children, according to the National Institutes of Health, affecting two to three of every 100,000 newborns.Leader Zheng-Rong Lu said that they believe this technology can deliver almost any type of gene to tackle inherited visual disorders.While other researchers focus on using modified viruses to deliver genes for therapy, sometimes the genes are too large for viruses to carry, Lu said. The protein is an essential constituent of the visual cycle that converts light to electrical signals to the brain.: A new gene-delivery system for an inherited form of blindness shows promise, according to a recent study.Researchers at Case Western Reserve University have developed gene-carrying nanoparticles that home in on target cells and prevent vision loss in mice with a human form of Leber congenital amaurosis.
They are also studying whether the nanoparticles can be used with the CRISPR/Cas9 gene-editing technique to treat genetic lesions related to retinal degenerative diseases.Though this research focused on the form of the disease called Leber congenital amaurosis 2, or LCA2, the scientists and engineers involved in the study believe the technology holds promise for other forms of LCA as well as other inherited diseases that lead to severe vision loss or blindness. The mutated gene fails to produce RPE65 protein in the retinal pigment epithelium (RPE), a cell layer critical for protecting photoreceptors (rods and cones). To track activity, Lus team included a fluorescent markerFollowing injection into the retina of mice,
The condition is one of the most common causes of blindness in children, according to the National Institutes of Health, affecting two to three of every 100,000 newborns.Leader Zheng-Rong Lu said that they believe this technology can deliver almost any type of gene to tackle inherited visual disorders.While other researchers focus on using modified viruses to deliver genes for therapy, sometimes the genes are too large for viruses to carry, Lu said. The protein is an essential constituent of the visual cycle that converts light to electrical signals to the brain.: A new gene-delivery system for an inherited form of blindness shows promise, according to a recent study.Researchers at Case Western Reserve University have developed gene-carrying nanoparticles that home in on target cells and prevent vision loss in mice with a human form of Leber congenital amaurosis.
They are also studying whether the nanoparticles can be used with the CRISPR/Cas9 gene-editing technique to treat genetic lesions related to retinal degenerative diseases.Though this research focused on the form of the disease called Leber congenital amaurosis 2, or LCA2, the scientists and engineers involved in the study believe the technology holds promise for other forms of LCA as well as other inherited diseases that lead to severe vision loss or blindness. The mutated gene fails to produce RPE65 protein in the retinal pigment epithelium (RPE), a cell layer critical for protecting photoreceptors (rods and cones). To track activity, Lus team included a fluorescent markerFollowing injection into the retina of mice,
Armaan Gupta working at his station
2021年4月25日 日常“It also has detachable sponges for maintenance. “At home, I had an almirah filled with the stuff I was making,” explains the 74-year-old innovator. The centre started with facilitating about 45-odd start-ups that soon became profitable companies.
The idea was to give people the ability to create innovative products to solve problems in their daily lives. Not just that, the innovators would be given a chance to exhibit their ideas. An initiated of Gaurang Shetty, CEO of Riddl, the customised maker initiative also exposes these energetic minds to their labs, in order to improve their products over a period of the two day fair.” While Armaan’s machine is still a model, he plans to produce more of these soon.Janaki and Girija are currently part of a unique fair called Maker Mela, which looks to host innovators, helping them find the right market.
Armaan Gupta working at his station at the mela“There are many young girls as well creating amazing stuff, but they don’t have a place to showcase it.“Our end is to create an opportunity for people,” he adds. Armaan’s contraption mops and dries the floor, simultaneously. “And we’ve created more than 200 job opportunities through our incubators.As a result, Amma Ki Almaari was born.Besides India, the mela has seen innovators from Taiwan, US and Europe over the past two years.The bamboo spinning wheel by Japanese innovator Hideo Oguri can be used anywhereRiddl, explains Garang, was set up in 2010 as an innovation centre and business incubator. To save myself, https://www.signs-factory.com/product/illuminated-sign/light-box-letter/ China light box signs Suppliers I came up with this mop,” grins Armaan. And both machines can be used anywhere!”Seeing the enthusiasm of the innovators, Gaurang hopes to take the mela abroad, starting with a mini version in Bangladesh.
And through this mela, we generate about 1,000 opportunities every year!”The Maker MelaOngoing till January 13, At Somaiya VidyaVihar.“I used to spill juice on the floor and get scolded by my mother. They now even have over 50 women on board from all over India, and the duo also help them curate products. Today, Amma Ki Almaari is more than just crochet — it’s an almari of different art and craft, all handmade,” explains Chatty Girija, who helps her mother Janaki runs the business. This time, 58-year-old Japanese innovator, Hideo Oguri is present. “The dehydrator has the capacity of only two clothes at the moment, but I plan to increase that.“The spin line is based on Mahatma Gandhi’s Charkha,” says Hideo.”Amma Ki AlmaariThe result sees the likes of 10-year-old Armaan Gupta, who is the creator of a remote-controlled cleaning and mopping machine. “As the almirah started filling up with material, my daughter thought of turning it into a business.And as innovators started to crowd in from across the world, Gaurang turned it into a mela, which now hosts 100 teams with three innovators in each.
“This concept is quite popular in the West, and we wanted to start something similar in India, but at a much evolved level.“We realised that building a community was useful, as alumni from Riddl started to come back to help the new start-ups,” smiled Gaurang.Having practiced crochet since the age of six, Chatty Janaki never imagined she’d make a business out of it. It was only three years ago that her daughter realised that there were more ‘ammas’ like her own, who had talent worth bringing to light. Starting off as only a destination for crochet work, Janaki now has an expansive spread of fabric art, wood art, and handmade jewellery. Hideo has made a spin line for cotton and a dehydrate laundry machine, which runs without electricity.
The idea was to give people the ability to create innovative products to solve problems in their daily lives. Not just that, the innovators would be given a chance to exhibit their ideas. An initiated of Gaurang Shetty, CEO of Riddl, the customised maker initiative also exposes these energetic minds to their labs, in order to improve their products over a period of the two day fair.” While Armaan’s machine is still a model, he plans to produce more of these soon.Janaki and Girija are currently part of a unique fair called Maker Mela, which looks to host innovators, helping them find the right market.
Armaan Gupta working at his station at the mela“There are many young girls as well creating amazing stuff, but they don’t have a place to showcase it.“Our end is to create an opportunity for people,” he adds. Armaan’s contraption mops and dries the floor, simultaneously. “And we’ve created more than 200 job opportunities through our incubators.As a result, Amma Ki Almaari was born.Besides India, the mela has seen innovators from Taiwan, US and Europe over the past two years.The bamboo spinning wheel by Japanese innovator Hideo Oguri can be used anywhereRiddl, explains Garang, was set up in 2010 as an innovation centre and business incubator. To save myself, https://www.signs-factory.com/product/illuminated-sign/light-box-letter/ China light box signs Suppliers I came up with this mop,” grins Armaan. And both machines can be used anywhere!”Seeing the enthusiasm of the innovators, Gaurang hopes to take the mela abroad, starting with a mini version in Bangladesh.
And through this mela, we generate about 1,000 opportunities every year!”The Maker MelaOngoing till January 13, At Somaiya VidyaVihar.“I used to spill juice on the floor and get scolded by my mother. They now even have over 50 women on board from all over India, and the duo also help them curate products. Today, Amma Ki Almaari is more than just crochet — it’s an almari of different art and craft, all handmade,” explains Chatty Girija, who helps her mother Janaki runs the business. This time, 58-year-old Japanese innovator, Hideo Oguri is present. “The dehydrator has the capacity of only two clothes at the moment, but I plan to increase that.“The spin line is based on Mahatma Gandhi’s Charkha,” says Hideo.”Amma Ki AlmaariThe result sees the likes of 10-year-old Armaan Gupta, who is the creator of a remote-controlled cleaning and mopping machine. “As the almirah started filling up with material, my daughter thought of turning it into a business.And as innovators started to crowd in from across the world, Gaurang turned it into a mela, which now hosts 100 teams with three innovators in each.
“This concept is quite popular in the West, and we wanted to start something similar in India, but at a much evolved level.“We realised that building a community was useful, as alumni from Riddl started to come back to help the new start-ups,” smiled Gaurang.Having practiced crochet since the age of six, Chatty Janaki never imagined she’d make a business out of it. It was only three years ago that her daughter realised that there were more ‘ammas’ like her own, who had talent worth bringing to light. Starting off as only a destination for crochet work, Janaki now has an expansive spread of fabric art, wood art, and handmade jewellery. Hideo has made a spin line for cotton and a dehydrate laundry machine, which runs without electricity.
